Natural Killer Cell Lymphoma: A Case with Classification Dilemma
Published: February 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/.7177
Ankit Kumar Jitani, Yookarin Khonglah, Ritesh Kumar, Bidyut Bikash Gogoi, Ekta Jajodia
1. Senior Resident, Department of Pathology, NEIGRIHMS, Shillong, Meghalaya, India.
2. Associate Professor, Department of Pathology, NEIGRIHMS, Shillong, Meghalaya, India.
3. Assistant Professor, Department of Oncology, NEIGRIHMS, Shillong, Meghalaya, India.
4. Junior Resident, Department of Pathology, NEIGRIHMS, Shillong, Meghalaya, India.
5. Junior Resident, Department of Pathology, NEIGRIHMS, Shillong, Meghalaya, India.
Correspondence
Dr. Yookarin Khonglah,
Associate Professor, Department of Pathology, NEIGRIHMS, Shillong- 793018, Meghalaya, India.
E-mail: yookarink@gmail.com
Non-Hodgkins lymphoma of the Natural Killer (NK) cell type is rare. World Health Organisation recognises 3 NK-cell phenotypic entities; extranodal NK/T cell lymphoma, nasal type (ENK/TL); aggressive NK cell leukaemia (ANKL); and chronic lymphoproliferative disorders of NK cells (CLPD-NK) which is classified as a provisional entity. Though specific clinical, morphological and immunophenotypic criteria have been laid down to diagnose these conditions there may however, be considerable variations in the clinical presentation making diagnosis difficult. We present a case with contrasting clinical and haematopathological findings posing difficulty in its diagnosis and classification, and despite the aggressive presentation showing favourable response to treatment.
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